Hypervitaminia B12: An Unknown Endocrine Marker

Zulfiqar A. A.; Sebaux A.; Andrès E.; Novella J. L.

doi:doi:10.11648/j.jfns.20150302.11

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Hypervitaminia B12: An Unknown Endocrine Marker

Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L.

Published in Journal of Food and Nutrition Sciences (Volume 3, Issue 2)

Received: 1 August 2014 Accepted: 10 February 2015 Published: 16 February 2015

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Abstract

Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy, renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.

Published in	Journal of Food and Nutrition Sciences (Volume 3, Issue 2)
DOI	10.11648/j.jfns.20150302.11
Page(s)	32-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hypervitaminia B12, Solid Neoplasms, Hemopathy, Renal Failure, Hepatic Disorders

References

[1]	Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr. 2011; 94(1):348S–358S.
[2]	Norredam K, Chainuvati T, Gimsing P, Hippe E, Viranuvatti V. Plasma cobalamin and transcobalamin in patients with primary carcinoma of the liver. A study from Thailand. Scand J Gastroenterol. 1983; 18(2):229–232.
[3]	Chiche L, Jean R, Romain F, et al. Clinical implications of high cobalamin blood levels for internal medicine. Rev Med Intern. 2008; 29(3):187–194.
[4]	Serraj K, Mecili M, Housni I, Andrès E. Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice. Presse Med. 2011;40(8):1120–1127.
[5]	Arendt JF, Nexo E. Cobalamin related parameters and disease patterns in patient’s with increased serum cobalamin levels. PLoS One. 2012; 7(9):e45979.
[6]	Arendt JF, Nexo E. Unexpected high plasma cobalamin: proposal for a diagnostic strategy. Clin Chem Lab Med. 2013; 51(3):489–496.
[7]	Johan Frederik Berg Arendt, Lars Pedersen, Ebba Nexo, Henrik Toft Sorensen. Elevated plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. JNCI 2013, Vol. 105, Issue 23 \| December 4.
[8]	Morkbak AL, Poulsen SS, Nexo E. Haptocorrin in humans. Clin Chem Lab Med. 2007; 45(12):1751–1759.
[9]	Zittoun J, Zittoun R, Marquet J, Sultan C. The three transcobalamin in myeloproliferative disorders and acute leukaemia. Br J Haematol. 1975; 31(3):287– 298.
[10]	Wheeler K, Pritchard J, Luck W, Rossiter M.Transcobalamin I as a marker for fibrolamellar hepatoma. Med Pediatr Oncol. 1986; 14(2): 227-9.
[11]	Geissbühler P, Mermillod B, Rapin C-H. Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients: A Prospective Study Over Five Years. J Pain Symptom Manage. 2000; 20(2):93–103.

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APA Style

Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L. (2015). Hypervitaminia B12: An Unknown Endocrine Marker. Journal of Food and Nutrition Sciences, 3(2), 32-34. https://doi.org/10.11648/j.jfns.20150302.11

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ACS Style

Zulfiqar A. A.; Sebaux A.; Andrès E.; Novella J. L. Hypervitaminia B12: An Unknown Endocrine Marker. J. Food Nutr. Sci. 2015, 3(2), 32-34. doi: 10.11648/j.jfns.20150302.11

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AMA Style

Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L. Hypervitaminia B12: An Unknown Endocrine Marker. J Food Nutr Sci. 2015;3(2):32-34. doi: 10.11648/j.jfns.20150302.11

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@article{10.11648/j.jfns.20150302.11,
  author = {Zulfiqar A. A. and Sebaux A. and Andrès E. and Novella J. L.},
  title = {Hypervitaminia B12: An Unknown Endocrine Marker},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {3},
  number = {2},
  pages = {32-34},
  doi = {10.11648/j.jfns.20150302.11},
  url = {https://doi.org/10.11648/j.jfns.20150302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20150302.11},
  abstract = {Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy,  renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.},
 year = {2015}
}

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TY  - JOUR
T1  - Hypervitaminia B12: An Unknown Endocrine Marker
AU  - Zulfiqar A. A.
AU  - Sebaux A.
AU  - Andrès E.
AU  - Novella J. L.
Y1  - 2015/02/16
PY  - 2015
N1  - https://doi.org/10.11648/j.jfns.20150302.11
DO  - 10.11648/j.jfns.20150302.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 32
EP  - 34
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20150302.11
AB  - Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy,  renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.
VL  - 3
IS  - 2
ER  -

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Author Information

Zulfiqar A. A.

Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France
Sebaux A.

Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France
Andrès E.

Department of Internal Medicine, University of Strasbourg, Strasbourg, France
Novella J. L.

Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France

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Plain Text BibTeX RIS

APA Style

Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L. (2015). Hypervitaminia B12: An Unknown Endocrine Marker. Journal of Food and Nutrition Sciences, 3(2), 32-34. https://doi.org/10.11648/j.jfns.20150302.11

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ACS Style

Zulfiqar A. A.; Sebaux A.; Andrès E.; Novella J. L. Hypervitaminia B12: An Unknown Endocrine Marker. J. Food Nutr. Sci. 2015, 3(2), 32-34. doi: 10.11648/j.jfns.20150302.11

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AMA Style

Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L. Hypervitaminia B12: An Unknown Endocrine Marker. J Food Nutr Sci. 2015;3(2):32-34. doi: 10.11648/j.jfns.20150302.11

Copy | Download

@article{10.11648/j.jfns.20150302.11,
  author = {Zulfiqar A. A. and Sebaux A. and Andrès E. and Novella J. L.},
  title = {Hypervitaminia B12: An Unknown Endocrine Marker},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {3},
  number = {2},
  pages = {32-34},
  doi = {10.11648/j.jfns.20150302.11},
  url = {https://doi.org/10.11648/j.jfns.20150302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20150302.11},
  abstract = {Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy,  renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Hypervitaminia B12: An Unknown Endocrine Marker
AU  - Zulfiqar A. A.
AU  - Sebaux A.
AU  - Andrès E.
AU  - Novella J. L.
Y1  - 2015/02/16
PY  - 2015
N1  - https://doi.org/10.11648/j.jfns.20150302.11
DO  - 10.11648/j.jfns.20150302.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 32
EP  - 34
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20150302.11
AB  - Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy,  renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.
VL  - 3
IS  - 2
ER  -

Copy | Download