Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes

Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet

doi:doi:10.11648/j.ijbse.s.2014020601.11

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Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes

Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet

Published in International Journal of Biomedical Science and Engineering (Volume 2, Issue 6-1)

Received: 19 July 2014 Accepted: 17 October 2014 Published: 5 November 2014

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Abstract

Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.

Published in	International Journal of Biomedical Science and Engineering (Volume 2, Issue 6-1) This article belongs to the Special Issue Cancer Research
DOI	10.11648/j.ijbse.s.2014020601.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Stem Cells, Myelodysplastic Syndrome, Microenvironment, Signaling Pathways, Therapy

References

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Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. (2014). Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. International Journal of Biomedical Science and Engineering, 2(6-1), 1-6. https://doi.org/10.11648/j.ijbse.s.2014020601.11

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Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int. J. Biomed. Sci. Eng. 2014, 2(6-1), 1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int J Biomed Sci Eng. 2014;2(6-1):1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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@article{10.11648/j.ijbse.s.2014020601.11,
  author = {Armel Herve Nwabo Kamdje and Paul Faustin Seke Etet},
  title = {Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {2},
  number = {6-1},
  pages = {1-6},
  doi = {10.11648/j.ijbse.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ijbse.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.s.2014020601.11},
  abstract = {Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.},
 year = {2014}
}

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AB  - Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.
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Armel Herve Nwabo Kamdje

Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Paul Faustin Seke Etet

Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia

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Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. (2014). Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. International Journal of Biomedical Science and Engineering, 2(6-1), 1-6. https://doi.org/10.11648/j.ijbse.s.2014020601.11

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ACS Style

Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int. J. Biomed. Sci. Eng. 2014, 2(6-1), 1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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AMA Style

Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int J Biomed Sci Eng. 2014;2(6-1):1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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@article{10.11648/j.ijbse.s.2014020601.11,
  author = {Armel Herve Nwabo Kamdje and Paul Faustin Seke Etet},
  title = {Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {2},
  number = {6-1},
  pages = {1-6},
  doi = {10.11648/j.ijbse.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ijbse.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.s.2014020601.11},
  abstract = {Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.},
 year = {2014}
}

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TY  - JOUR
T1  - Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes
AU  - Armel Herve Nwabo Kamdje
AU  - Paul Faustin Seke Etet
Y1  - 2014/11/05
PY  - 2014
N1  - https://doi.org/10.11648/j.ijbse.s.2014020601.11
DO  - 10.11648/j.ijbse.s.2014020601.11
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.s.2014020601.11
AB  - Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.
VL  - 2
IS  - 6-1
ER  -

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