The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair

Ayad H.; Zahra M.; Gabr H.; Ismaeil A.; Abo Elkheir Y.

doi:doi:10.11648/j.bio.s.2015030401.13

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The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair

Ayad H., Zahra M., Gabr H., Ismaeil A., Abo Elkheir Y.

Published in American Journal of Bioscience and Bioengineering (Volume 3, Issue 4-1)

Received: 29 May 2015 Accepted: 1 June 2015 Published: 30 June 2015

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Abstract

Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of peripheral nerve injuries. Subjects and Methods: This study was conducted on 18 patients with recent trauma involving nerve injuries at the wrist region. Patients were divided into: Group I: underwent surgical end-to-end closure GroupII: underwent surgical end-to-end closure and injection of ADSCs into the nerve sheath and surrounding tissue. Both groups were followed up using clinical assessment using Sensory Recovery Grading and Muscle Strength Grading systems in addition to electrophysiological nerve conduction tests. Results and Conclusions: This study collected a range of 1 to 2 x106 ADSCs from an average of 100-150 ml fat. After 1 year, stem cell group showed significantly higher motor and sensory improvement in ulnar nerve injury; while in the median nerve injury, stem cell group showed higher motor recovery with no difference in sensory recovery.

Published in	American Journal of Bioscience and Bioengineering (Volume 3, Issue 4-1) This article belongs to the Special Issue Stem Cells for Neuro-Regeneration: Where Do We Stand
DOI	10.11648/j.bio.s.2015030401.13
Page(s)	18-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Peripheral Nerve, Adipose Stem Cells, Regeneration

References

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APA Style

Ayad H., Zahra M., Gabr H., Ismaeil A., Abo Elkheir Y. (2015). The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. American Journal of Bioscience and Bioengineering, 3(4-1), 18-23. https://doi.org/10.11648/j.bio.s.2015030401.13

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ACS Style

Ayad H.; Zahra M.; Gabr H.; Ismaeil A.; Abo Elkheir Y. The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. Am. J. BioSci. Bioeng. 2015, 3(4-1), 18-23. doi: 10.11648/j.bio.s.2015030401.13

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AMA Style

Ayad H., Zahra M., Gabr H., Ismaeil A., Abo Elkheir Y. The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. Am J BioSci Bioeng. 2015;3(4-1):18-23. doi: 10.11648/j.bio.s.2015030401.13

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@article{10.11648/j.bio.s.2015030401.13,
  author = {Ayad H. and Zahra M. and Gabr H. and Ismaeil A. and Abo Elkheir Y.},
  title = {The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {4-1},
  pages = {18-23},
  doi = {10.11648/j.bio.s.2015030401.13},
  url = {https://doi.org/10.11648/j.bio.s.2015030401.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.s.2015030401.13},
  abstract = {Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of peripheral nerve injuries. Subjects and Methods: This study was conducted on 18 patients with recent trauma involving nerve injuries at the wrist region. Patients were divided into: Group I: underwent surgical end-to-end closure GroupII: underwent surgical end-to-end closure and injection of ADSCs into the nerve sheath and surrounding tissue. Both groups were followed up using clinical assessment using Sensory Recovery Grading and Muscle Strength Grading systems in addition to electrophysiological nerve conduction tests. Results and Conclusions: This study collected a range of 1 to 2 x106 ADSCs from an average of 100-150 ml fat. After 1 year, stem cell group showed significantly higher motor and sensory improvement in ulnar nerve injury; while in the median nerve injury, stem cell group showed higher motor recovery with no difference in sensory recovery.},
 year = {2015}
}

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TY  - JOUR
T1  - The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair
AU  - Ayad H.
AU  - Zahra M.
AU  - Gabr H.
AU  - Ismaeil A.
AU  - Abo Elkheir Y.
Y1  - 2015/06/30
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.s.2015030401.13
DO  - 10.11648/j.bio.s.2015030401.13
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 18
EP  - 23
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.s.2015030401.13
AB  - Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of peripheral nerve injuries. Subjects and Methods: This study was conducted on 18 patients with recent trauma involving nerve injuries at the wrist region. Patients were divided into: Group I: underwent surgical end-to-end closure GroupII: underwent surgical end-to-end closure and injection of ADSCs into the nerve sheath and surrounding tissue. Both groups were followed up using clinical assessment using Sensory Recovery Grading and Muscle Strength Grading systems in addition to electrophysiological nerve conduction tests. Results and Conclusions: This study collected a range of 1 to 2 x106 ADSCs from an average of 100-150 ml fat. After 1 year, stem cell group showed significantly higher motor and sensory improvement in ulnar nerve injury; while in the median nerve injury, stem cell group showed higher motor recovery with no difference in sensory recovery.
VL  - 3
IS  - 4-1
ER  -

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Author Information

Ayad H.

Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Zahra M.

Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Gabr H.

Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Ismaeil A.

Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Abo Elkheir Y.

Tissue Culture and Vaccine Department, VACSERA, Cairo, Egypt

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APA Style

Ayad H., Zahra M., Gabr H., Ismaeil A., Abo Elkheir Y. (2015). The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. American Journal of Bioscience and Bioengineering, 3(4-1), 18-23. https://doi.org/10.11648/j.bio.s.2015030401.13

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ACS Style

Ayad H.; Zahra M.; Gabr H.; Ismaeil A.; Abo Elkheir Y. The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. Am. J. BioSci. Bioeng. 2015, 3(4-1), 18-23. doi: 10.11648/j.bio.s.2015030401.13

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AMA Style

Ayad H., Zahra M., Gabr H., Ismaeil A., Abo Elkheir Y. The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair. Am J BioSci Bioeng. 2015;3(4-1):18-23. doi: 10.11648/j.bio.s.2015030401.13

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@article{10.11648/j.bio.s.2015030401.13,
  author = {Ayad H. and Zahra M. and Gabr H. and Ismaeil A. and Abo Elkheir Y.},
  title = {The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {4-1},
  pages = {18-23},
  doi = {10.11648/j.bio.s.2015030401.13},
  url = {https://doi.org/10.11648/j.bio.s.2015030401.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.s.2015030401.13},
  abstract = {Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of peripheral nerve injuries. Subjects and Methods: This study was conducted on 18 patients with recent trauma involving nerve injuries at the wrist region. Patients were divided into: Group I: underwent surgical end-to-end closure GroupII: underwent surgical end-to-end closure and injection of ADSCs into the nerve sheath and surrounding tissue. Both groups were followed up using clinical assessment using Sensory Recovery Grading and Muscle Strength Grading systems in addition to electrophysiological nerve conduction tests. Results and Conclusions: This study collected a range of 1 to 2 x106 ADSCs from an average of 100-150 ml fat. After 1 year, stem cell group showed significantly higher motor and sensory improvement in ulnar nerve injury; while in the median nerve injury, stem cell group showed higher motor recovery with no difference in sensory recovery.},
 year = {2015}
}

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TY  - JOUR
T1  - The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair
AU  - Ayad H.
AU  - Zahra M.
AU  - Gabr H.
AU  - Ismaeil A.
AU  - Abo Elkheir Y.
Y1  - 2015/06/30
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.s.2015030401.13
DO  - 10.11648/j.bio.s.2015030401.13
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 18
EP  - 23
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.s.2015030401.13
AB  - Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of peripheral nerve injuries. Subjects and Methods: This study was conducted on 18 patients with recent trauma involving nerve injuries at the wrist region. Patients were divided into: Group I: underwent surgical end-to-end closure GroupII: underwent surgical end-to-end closure and injection of ADSCs into the nerve sheath and surrounding tissue. Both groups were followed up using clinical assessment using Sensory Recovery Grading and Muscle Strength Grading systems in addition to electrophysiological nerve conduction tests. Results and Conclusions: This study collected a range of 1 to 2 x106 ADSCs from an average of 100-150 ml fat. After 1 year, stem cell group showed significantly higher motor and sensory improvement in ulnar nerve injury; while in the median nerve injury, stem cell group showed higher motor recovery with no difference in sensory recovery.
VL  - 3
IS  - 4-1
ER  -

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