The several antibacterial activities of wonderful kola plant (i.e. Buchholzia coriacea) has necessitated the need for a high-throughput and molecular characterization of all the bioactive components from the plant as a panacea to discovering bioactive compounds which could serve as lead compounds in developing potent and novel antibacterial agents. Microbial resistance to some available antimicrobial agents necessitates the need to search for newer antimicrobial agents that will not be easily amenable to the attack of resistant strains of microorganisms (many of which remain active even in the face of antimicrobial onslaught). This study investigates the phytochemical constituents and antibacterial activity of leaf extracts of wonderful kola on pathogenic Staphylococcus aureus strains. Antibacterial activity of the wonderful kola plant extract was evaluated by the agar well diffusion method to determine the zones of inhibition and minimum inhibitory concentration (MIC). Phytochemical analysis revealed that wonderful kola leaf contains phlobatannins, carbohydrates, proteins, tannins, saponins, alkaloids and flavonoids. Varying zones of inhibition was produced by the ethanol extract (10-14 mm) and methanol extracts (13-15 mm) against the S. aureus strains. MIC for both the ethanol and methanol extracts was recorded at 50 mg/ml and 100 mg/ml for some strains of the S. aureus. The results of this study have shown and contributed to the potential of wonderful kola leaf extracts in inhibiting pathogenic strains of S. aureus. Further high-throughput technologies are required to characterize the main bioactive constituents of the wonderful kola plant extracts so that they can be compounded into drug formulations for the treatment of some bacterial related infections in this part of the world.
| Published in |
American Journal of Life Sciences (Volume 2, Issue 6-3)
This article belongs to the Special Issue Microbiology Research |
| DOI | 10.11648/j.ajls.s.2014020603.12 |
| Page(s) | 9-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Wonderful Kola, Gram Negative Bacteria, Resistance, Nigeria
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APA Style
Ejikeugwu Chika, Umeokoli Blessing, Iroha Ifeanyichukwu, Ugwu Malachy, Esimone Charles. (2014). Phytochemical and Antibacterial Screening of Crude Extracts from Leaves of Wonderful Kola. American Journal of Life Sciences, 2(6-3), 9-12. https://doi.org/10.11648/j.ajls.s.2014020603.12
ACS Style
Ejikeugwu Chika; Umeokoli Blessing; Iroha Ifeanyichukwu; Ugwu Malachy; Esimone Charles. Phytochemical and Antibacterial Screening of Crude Extracts from Leaves of Wonderful Kola. Am. J. Life Sci. 2014, 2(6-3), 9-12. doi: 10.11648/j.ajls.s.2014020603.12
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Download@article{10.11648/j.ajls.s.2014020603.12,
author = {Ejikeugwu Chika and Umeokoli Blessing and Iroha Ifeanyichukwu and Ugwu Malachy and Esimone Charles},
title = {Phytochemical and Antibacterial Screening of Crude Extracts from Leaves of Wonderful Kola},
journal = {American Journal of Life Sciences},
volume = {2},
number = {6-3},
pages = {9-12},
doi = {10.11648/j.ajls.s.2014020603.12},
url = {https://doi.org/10.11648/j.ajls.s.2014020603.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2014020603.12},
abstract = {The several antibacterial activities of wonderful kola plant (i.e. Buchholzia coriacea) has necessitated the need for a high-throughput and molecular characterization of all the bioactive components from the plant as a panacea to discovering bioactive compounds which could serve as lead compounds in developing potent and novel antibacterial agents. Microbial resistance to some available antimicrobial agents necessitates the need to search for newer antimicrobial agents that will not be easily amenable to the attack of resistant strains of microorganisms (many of which remain active even in the face of antimicrobial onslaught). This study investigates the phytochemical constituents and antibacterial activity of leaf extracts of wonderful kola on pathogenic Staphylococcus aureus strains. Antibacterial activity of the wonderful kola plant extract was evaluated by the agar well diffusion method to determine the zones of inhibition and minimum inhibitory concentration (MIC). Phytochemical analysis revealed that wonderful kola leaf contains phlobatannins, carbohydrates, proteins, tannins, saponins, alkaloids and flavonoids. Varying zones of inhibition was produced by the ethanol extract (10-14 mm) and methanol extracts (13-15 mm) against the S. aureus strains. MIC for both the ethanol and methanol extracts was recorded at 50 mg/ml and 100 mg/ml for some strains of the S. aureus. The results of this study have shown and contributed to the potential of wonderful kola leaf extracts in inhibiting pathogenic strains of S. aureus. Further high-throughput technologies are required to characterize the main bioactive constituents of the wonderful kola plant extracts so that they can be compounded into drug formulations for the treatment of some bacterial related infections in this part of the world.},
year = {2014}
}
TY - JOUR T1 - Phytochemical and Antibacterial Screening of Crude Extracts from Leaves of Wonderful Kola AU - Ejikeugwu Chika AU - Umeokoli Blessing AU - Iroha Ifeanyichukwu AU - Ugwu Malachy AU - Esimone Charles Y1 - 2014/09/30 PY - 2014 N1 - https://doi.org/10.11648/j.ajls.s.2014020603.12 DO - 10.11648/j.ajls.s.2014020603.12 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 9 EP - 12 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2014020603.12 AB - The several antibacterial activities of wonderful kola plant (i.e. Buchholzia coriacea) has necessitated the need for a high-throughput and molecular characterization of all the bioactive components from the plant as a panacea to discovering bioactive compounds which could serve as lead compounds in developing potent and novel antibacterial agents. Microbial resistance to some available antimicrobial agents necessitates the need to search for newer antimicrobial agents that will not be easily amenable to the attack of resistant strains of microorganisms (many of which remain active even in the face of antimicrobial onslaught). This study investigates the phytochemical constituents and antibacterial activity of leaf extracts of wonderful kola on pathogenic Staphylococcus aureus strains. Antibacterial activity of the wonderful kola plant extract was evaluated by the agar well diffusion method to determine the zones of inhibition and minimum inhibitory concentration (MIC). Phytochemical analysis revealed that wonderful kola leaf contains phlobatannins, carbohydrates, proteins, tannins, saponins, alkaloids and flavonoids. Varying zones of inhibition was produced by the ethanol extract (10-14 mm) and methanol extracts (13-15 mm) against the S. aureus strains. MIC for both the ethanol and methanol extracts was recorded at 50 mg/ml and 100 mg/ml for some strains of the S. aureus. The results of this study have shown and contributed to the potential of wonderful kola leaf extracts in inhibiting pathogenic strains of S. aureus. Further high-throughput technologies are required to characterize the main bioactive constituents of the wonderful kola plant extracts so that they can be compounded into drug formulations for the treatment of some bacterial related infections in this part of the world. VL - 2 IS - 6-3 ER -
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