@article{10.11648/j.ajbls.20160404.12,
  author = {Akram Mohammed-Refat Altaher and Salem Sami Alewaity and Jalal Ahmed Abu-Touima},
  title = {Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {4},
  number = {4},
  pages = {61-68},
  doi = {10.11648/j.ajbls.20160404.12},
  url = {https://doi.org/10.11648/j.ajbls.20160404.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20160404.12},
  abstract = {Background: Type 1 diabetes mellitus (T1DM) is a group of metabolic diseases characterized by hyperglycemia resulting from autoimmune destructions of β cells lead to lack or sever reduction in insulin secretion. Coronary heart disease (CHD) is more prevalent among DM patients than other population. Higher risk of CHD is seen in DM patients who are smokers, have lipid abnormalities, obese, and hypertension. Objective: The overall aim of this study is to evaluate serum lipid profiles of patients with T1DM in comparison with age matched controls in Gaza Strip, Palestine. Materials and Methods: This study was a case control started in Jan, 2014 and finished in Sept, 2014. A total of 50 T1DM patients as a cases group and 100 age-matched healthy individuals as a controls group, aged between 3-18 years. Personal & demographic data, and clinical data situation of the study population were taken by interview questionnaire. Anthropometric and biochemical evaluation were carried out. Collected data and biochemical analysis were analyzed using SPSS version 18. Results: There was no statistically differences among the study subjects with respect to age (P=0.729). Regarding to gender, there was a statistically difference among the study subjects with respect to gender (P=0.014). Concerning the body mass index (BMI), the results reported that there was no statistically difference among the study subjects with respect to BMI (P=0.146). Regarding lipid profiles, this research found that the percentage of high serum triglycerides (TGs) levels was significantly higher among diabetic patients than in controls (p=0.001), However both of them have normal TGs levels, generally. Moreover, despite of both of T1DM and controls in generally, have a normal levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), there were no statistically significant differences among both of them according to these biochemical parameters (p>0.05). On the other hand, there was no relationship between the lipid profiles in T1DM patients and the gender, family history and duration of DM, and BMI, except that, elevation of TGs levels was significantly higher in diabetic males as compared to diabetic females (p=0.011). Conclusions: T1DM patients group and control group were appeared with little or no progressing towards the emergence atherosclerosis and coronary risk factors; because, mostly, they were having normal serum TC, LDL-C &, TGs with low or normal BMI.},
 year = {2016}
}

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TY  - JOUR
T1  - Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip
AU  - Akram Mohammed-Refat Altaher
AU  - Salem Sami Alewaity
AU  - Jalal Ahmed Abu-Touima
Y1  - 2016/07/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ajbls.20160404.12
DO  - 10.11648/j.ajbls.20160404.12
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 61
EP  - 68
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20160404.12
AB  - Background: Type 1 diabetes mellitus (T1DM) is a group of metabolic diseases characterized by hyperglycemia resulting from autoimmune destructions of β cells lead to lack or sever reduction in insulin secretion. Coronary heart disease (CHD) is more prevalent among DM patients than other population. Higher risk of CHD is seen in DM patients who are smokers, have lipid abnormalities, obese, and hypertension. Objective: The overall aim of this study is to evaluate serum lipid profiles of patients with T1DM in comparison with age matched controls in Gaza Strip, Palestine. Materials and Methods: This study was a case control started in Jan, 2014 and finished in Sept, 2014. A total of 50 T1DM patients as a cases group and 100 age-matched healthy individuals as a controls group, aged between 3-18 years. Personal & demographic data, and clinical data situation of the study population were taken by interview questionnaire. Anthropometric and biochemical evaluation were carried out. Collected data and biochemical analysis were analyzed using SPSS version 18. Results: There was no statistically differences among the study subjects with respect to age (P=0.729). Regarding to gender, there was a statistically difference among the study subjects with respect to gender (P=0.014). Concerning the body mass index (BMI), the results reported that there was no statistically difference among the study subjects with respect to BMI (P=0.146). Regarding lipid profiles, this research found that the percentage of high serum triglycerides (TGs) levels was significantly higher among diabetic patients than in controls (p=0.001), However both of them have normal TGs levels, generally. Moreover, despite of both of T1DM and controls in generally, have a normal levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), there were no statistically significant differences among both of them according to these biochemical parameters (p>0.05). On the other hand, there was no relationship between the lipid profiles in T1DM patients and the gender, family history and duration of DM, and BMI, except that, elevation of TGs levels was significantly higher in diabetic males as compared to diabetic females (p=0.011). Conclusions: T1DM patients group and control group were appeared with little or no progressing towards the emergence atherosclerosis and coronary risk factors; because, mostly, they were having normal serum TC, LDL-C &, TGs with low or normal BMI.
VL  - 4
IS  - 4
ER  - 

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